United States Medical Licensing Examination (USMLE) Test Prep

We know taking the USMLE is a big step in your medical career. We’ve compile the USMLE Question Bank into two categories, Psychiatry and Neurology, to streamline your access to clinical, high yield questions that will help you prepare for your Step 2 Test.

USMLE Question Bank

Step 2, Clinical Knowledge

The USMLE Question Bank is comprised of video vignettes, multiset vignettes, and multiple choice questions that are high yield and targeted to enhance your clinical knowledge in order to help you prepare most for taking the USMLE Step 2.

We are constantly updating our question banks by researching the most current and up to date information, and giving you the resources you need to succeed!

Streamlined Topics

We’ve streamlined the questions into two topic categories: Psychiatry and Neurology. These topics cover the full range of clinical knowledge your need to know, as well as a full bank of neurology, neuroscience, neurodevelopment, and neurological testing. This means you’ll be more than prepared to pass your exam with flying colors after utilizing our question banks for the exam.

Samples of the questions we offer in our USMLE question bank- Click to see more!

Example Single Response Multiple Choice- Click to see answer!

A 45-year-old male with a history of depression and recent diagnosis of bipolar II disorder presents to your clinic to establish care. He notes several prior medication trials including paroxetine, duloxetine, and aripiprazole, none of which have been helpful for his depressive symptoms. Currently he has had several months of low mood, insomnia, low appetite, low energy, and concentration difficulties; he would like a medication that will adequately treat his depressive symptoms. Which of the following agents has the best evidence for management of acute depression in bipolar II disorder?

A Quetiapine

B Lithium

C Lamotrigine

D Divalproex

E Ziprasidone

Example Single Response Multiple Choice- Answer

Correct Answer- A Quetiapine

Explanation:

The Canadian Network for Mood and Anxiety Treatments (CANMAT), in collaboration with the International Society for Bipolar Disorders (ISBD) published updated and widely regarded treatment guidelines for bipolar disorder in 2018. Recommendations outline first, second, and third-line treatments for acute mania, acute depression, and maintenance treatment, with consideration for levels of evidence for efficacy, clinical support based on experience, and consensus ratings for safety, tolerability, and treatment-emergent switch risk. In addition to guidelines for management of bipolar I disorder, CANMAT/ISBD have also provided recommendations for treatment of depression in bipolar II disorder. Of note, the specific treatment of bipolar II disorder has been understudied relative to bipolar I disorder. Quetiapine is a first-line agent for acute management of bipolar II depression, equally effective in both bipolar I and bipolar II depression (Choice A). Lithium (Choice B) and lamotrigine (Choice C) are second-line recommendations given mixed results, likely due to methodological issues in studies. Divalproex (Choice D) and ziprasidone (Choice E) are third-line options for acute management of bipolar II depression.

REF:
1-Yatham LN et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder. Bipolar Disord 2018 Mar;20(2):97-170.

Example Multiset Vignette

Ann is a 45-year-old woman. She describes a long history of “not fitting in” and feeling misunderstood. Ann reports her history tearfully, frequently grabbing tissues from her pocket and stating how “destroyed and empty” she is. She reports migraines that are treated by triptan. She is also diagnosed with sleep apnea. However, she is non-compliant with her CPAP machine. Her BMI is 41. Ann reports that she was in a long-term relationship with a male partner for 14 years. She reports that Ron was a “perfect prince that turned into a nightmare.” She admits to breaking his computer during the last fight. After many breakups and reconciliations, he recently ended the relationship and moved out citing her “inability to be happy” and said she was emotionally abusive. Ann reports that she is actually the victim of his emotional abuse and acts out by engaging in sex outside of the relationship. While her partner, Ron, was moving his things out of the apartment, she reported repeatedly texting and calling him until he answered. She also made superficial cuts on her arm with Ron’s initials. She reports she told Ron he could “tell the police they would find her on the bathroom floor.” Ron called 911 and Ann was taken to a nearby emergency room by ambulance for evaluation last night. She was given an outpatient referral to your office.

Q1 Ann reports that Ron is wrong for having abandoned her and intimates she might try to reconcile with him again. What is Ann’s most likely diagnosis?

A Histrionic personality disorder

B Dependent personality disorder

C Narcissistic personality disorder

D Borderline personality disorder

E Major depressive disorder

Example Multiset Vignette Continued

Ann is a 45-year-old woman. She describes a long history of “not fitting in” and feeling misunderstood. Ann reports her history tearfully, frequently grabbing tissues from her pocket and stating how “destroyed and empty” she is. She reports migraines that are treated by triptan. She is also diagnosed with sleep apnea. However, she is non-compliant with her CPAP machine. Her BMI is 41. Ann reports that she was in a long-term relationship with a male partner for 14 years. She reports that Ron was a “perfect prince that turned into a nightmare.” She admits to breaking his computer during the last fight. After many breakups and reconciliations, he recently ended the relationship and moved out citing her “inability to be happy” and said she was emotionally abusive. Ann reports that she is actually the victim of his emotional abuse and acts out by engaging in sex outside of the relationship. While her partner, Ron, was moving his things out of the apartment, she reported repeatedly texting and calling him until he answered. She also made superficial cuts on her arm with Ron’s initials. She reports she told Ron he could “tell the police they would find her on the bathroom floor.” Ron called 911 and Ann was taken to a nearby emergency room by ambulance for evaluation last night. She was given an outpatient referral to your office.

Q2 What other symptoms would you expect for Ann to display?

A Paranoid ideation concerning hospital staff

B Identity struggles

C Rigidity and stubbornness

D Grandiose sense of self-importance

E Paranoid thoughts

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